Quote from: Crosscut on Yesterday at 01:16:53 PMJust in general, PVP-I is a good choice for a SHTF antiseptic regardless.^^^^ ---- This bears repeating...
QuoteMore than 100 million Americans have received a smallpox vaccination, and a question arising from this report is: how might protective immunity against monkeypox relate to protection against smallpox? With smallpox extinct in nature, it is not possible to determine the key immunological requirements for full protection in humans. Monkeypox, however, serves as an informative surrogate for smallpox in that it is a human pathogen capable of inducing lethal infections in 4–25% of those afflicted and smallpox vaccination is cross-protective. We examined the immune responses and clinical outcome of subjects infected with a West African strain of monkeypox, which may or may not show the same mortality rates observed in previous monkeypox outbreaks. Many factors have a role in monkeypox-induced mortality, including the strain of virus involved, the
route of infection, the age, nutritional status, immune status and vaccination status of the host, and access to sophisticated medical care13. Here we identified five vaccinated subjects who contracted monkeypox and three vaccinated subjects who showed full protection against the onset of monkeypox-induced disease. Although this sample size is too small to make concrete statistical estimations, it broadly suggests that almost half of vaccinated individuals (3 ofmaintain long-term protective immunity against monkeypox.
Notably, previous analysis of vaccinia-specific antibody levels in 4300 vaccinees showed that B50% have neutralizing antibody titers of Z1:32 (ref. 14), which prior reports suggested would provide fully protective immunity against smallpox. In a study involving 4300 subjects, the overt smallpox attack rate (i.e., clinical disease symptoms after exposure) was 68.8% among unvaccinated contacts, compared to only 3.2% in vaccinated contacts. Notably, 55% (78 of 142) of vaccinated household contacts had clinically inapparent smallpox infections, indicative of preexisting, fully protective immunity. The main (albeit speculative) point of this current study is that our findings are consistent with what would have been predicted by this much larger previous report and show that some level of protective immunity probably exists in contemporary subjects who have received smallpox vaccination in the distant past.
Quote from: majorhavoc on Yesterday at 02:10:18 PMQuote from: 12_Gauge_Chimp on Yesterday at 01:51:11 PMIf that is true, it would be a seismic event. I'm not seeing anything on my news feeds.Quote from: NT2C on Yesterday at 01:36:02 PMQuote from: mzmc on Yesterday at 10:46:30 AMI honestly would have thought the Chinese would be getting up to more seedy and/or sneaky crap while the world is distracted.More likely, he's watching and taking notes of what not to do when China eventually goes after Taiwan.
Guess Xi still has, *ahem*, matters or internal security to settle and isn't really keen on rocking the boat on an international scale.
Didn't he supposedly have a brain hemorrhage or something ?
I seem to recall reading something recently about Xi having a medical emergency, but the article was kind of vague and only mentioned something pertaining to a possible brain issue.
Quote from: 12_Gauge_Chimp on Yesterday at 01:51:11 PMIf that is true, it would be a seismic event. I'm not seeing anything on my news feeds.Quote from: NT2C on Yesterday at 01:36:02 PMQuote from: mzmc on Yesterday at 10:46:30 AMI honestly would have thought the Chinese would be getting up to more seedy and/or sneaky crap while the world is distracted.More likely, he's watching and taking notes of what not to do when China eventually goes after Taiwan.
Guess Xi still has, *ahem*, matters or internal security to settle and isn't really keen on rocking the boat on an international scale.
Didn't he supposedly have a brain hemorrhage or something ?
I seem to recall reading something recently about Xi having a medical emergency, but the article was kind of vague and only mentioned something pertaining to a possible brain issue.
Quote from: NT2C on Yesterday at 01:36:02 PMQuote from: mzmc on Yesterday at 10:46:30 AMI honestly would have thought the Chinese would be getting up to more seedy and/or sneaky crap while the world is distracted.More likely, he's watching and taking notes of what not to do when China eventually goes after Taiwan.
Guess Xi still has, *ahem*, matters or internal security to settle and isn't really keen on rocking the boat on an international scale.
Quote from: mzmc on Yesterday at 10:46:30 AMI honestly would have thought the Chinese would be getting up to more seedy and/or sneaky crap while the world is distracted.More likely, he's watching and taking notes of what not to do when China eventually goes after Taiwan.
Guess Xi still has, *ahem*, matters or internal security to settle and isn't really keen on rocking the boat on an international scale.
QuoteIn these studies, we tested the efficacy of topical PIO administration as a means to reduce virus shedding from the skin following traditional smallpox vaccination. This topical agent was highly effective at reducing or eliminating infectious virus on the skin surface and on the bandages used to cover the vaccination site.
QuoteDespite proper instruction and care of the vaccination site, contact spread of vaccinia virus and ocular infections continue to be a problem among vaccinated military personnel [38]. This has led to secondary and even tertiary transfer of the virus in rare instances
QuoteAnother potential use for topical antivirals may also be as a form of primary prophylaxis by administering ointment on exposed skin of medical personnel or predisposed individuals with atopic dermatitis if they inadvertently come into contact with a recently vaccinated individual. Although washing with soap and water is typically recommended, some detergents (data not shown) and commercial soaps [41] perform poorly at inactivating vaccinia virus. Because PIO administration is generally well tolerated, application of this antimicrobial ointment may be useful for treating other orthopoxvirus infections besides vaccinia. If smallpox were to be released during a bioterrorism event, PIO could be administered directly onto the skin lesions of the patients in order to reduce the risk of fomite spread in the hospital or clinic and/or during transport to designated quarantine sites. This may also be a useful approach to treating monkeypox patients during outbreaks that continue to occur in the Democratic Republic of Congo and possibly other neighboring countries [42, 43]. In this setting, PIO represents an affordable method for reducing virus transmission while at the same time helping to prevent secondary bacterial infections during the pustular stages of disease.